Tutorial de Modelagem Farmacocinética Baseada em Fisiologia (PBPK) em Programa de Acesso Livre

Abstract

Objectives: To broaden the study of PBPK modeling for Portuguese-speaking professionals and students by developing a basic simple PBPK modeling tutorial using free access software. Methods: For tutorial development, the PK-Sim® software was used. Results: A tutorial was developed in PK-Sim, completely in Portuguese, which will enable readers to perform a PBPK analysis to provide a mechanistic approach to study and predict the pharmacokinetics of medicines based on the physiological and anatomical characteristics of a population of interest, as well as in the physical and chemical properties of a particular drug. Conclusions: Considering the importance of health technologies and their subsequent assessment, this tutorial proves as a relevant tool, both for research and development and for clinical practice, as well as leveraging the democratization of the teaching and research of Pharmaceutical Sciences among Portuguese-speaking people.