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Abstract
Objective: The present study assessed, at national and international levels, the agreement of information sources that guide pediatric prescription of antimicrobials for pharyngotonsillitis, acute otitis media and rhinosinusitis, in relation to the drug of choice, dosage and types of references used in its preparation. Method: Documents from Brazilian and international entities and the package inserts of the medications mentioned in these documents were selected. To three diseases, were analyzed 14 different documents. Results: The penicillin class was prevalent as first-line therapy in the three diseases investigated. However, there was great variation in the doses indicated and in the way they are expressed. The minimum age for use was reported in 54.3% of the sources, being less recurrent in national sources. Duration of treatment was present in 64.4% of the drugs indicated in the sources. In general, the sources analyzed for the three disorders investigated most often cite references classified as review articles and experimental studies, followed by formularies and official lists to support their data. Conclusion: The results obtained reinforce the need to encourage clinical trials and/or Pharmacometrics studies for establishing dosing recommendations of antimicrobials for pediatric patients, as well as to harmonize the information provided to guide prescriptions.
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